Abstract
The synthesis and structure-activity profile of a new class of potent and highly specific thromboxane A2 synthetase inhibitors is described. The most potent member of this series in vitro is determined to be imidazo[1,5-a]-pyridine-5-hexanoic acid (9).
MeSH terms
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Animals
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Blood Platelets / enzymology
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Cattle
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Cytochrome P-450 Enzyme System*
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Epoprostenol / biosynthesis
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Epoprostenol / metabolism
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Humans
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Intramolecular Oxidoreductases*
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Male
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Oxidoreductases / antagonists & inhibitors*
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Prostaglandin-Endoperoxide Synthases / metabolism
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Pyridines / chemical synthesis*
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Pyridines / pharmacology
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Sheep
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Structure-Activity Relationship
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Thromboxane A2 / biosynthesis*
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Thromboxane-A Synthase / antagonists & inhibitors*
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Thromboxanes / biosynthesis*
Substances
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Imidazoles
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Pyridines
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Thromboxanes
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Thromboxane A2
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Cytochrome P-450 Enzyme System
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Epoprostenol
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Oxidoreductases
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Prostaglandin-Endoperoxide Synthases
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Intramolecular Oxidoreductases
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prostacyclin synthetase
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Thromboxane-A Synthase